mouse EIF2AK2 Over-expression AAV

Cat. No: AAV-258182

Availability: 3-5 weeks

Name: AAV-m-EIF2AK2

This is an AAV expressing Mouse Eif2ak2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Eif2ak2
Gene Name: eukaryotic translation initiation factor 2-alpha kinase 2
Gene ID: 19106
Gene Synonyms: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; Pkr; Prkr; Tik
ORF Size: 1548 bp
RefSeq#: BC016422
Gene Description: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
UniGene ID: Mm.378990