human TDO2 Over-expression AAV

Cat. No: AAV-225263

Availability: 3-5 weeks

Name: AAV-h-TDO2

This is an AAV expressing Human TDO2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TDO2
Gene Name: tryptophan 2,3-dioxygenase
Gene ID: 6999
Gene Synonyms: TDO; TO; TPH2; TRPO
ORF Size: 1221 bp
RefSeq#: BC005355
Gene Description: TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
UniGene ID: Hs.183671
HGNC ID: HGNC:11708