human PDZK1 Over-expression AAV

Cat. No: AAV-218579

Availability: 3-5 weeks

Name: AAV-h-PDZK1

This is an AAV expressing Human PDZK1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDZK1
Gene Name: PDZ domain containing 1
Gene ID: 5174
Gene Synonyms: CAP70; CLAMP; NHERF-3; NHERF3; PDZD1
ORF Size: 1560 bp
RefSeq#: BC006496
Gene Description: PDZK1 encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.444751
HGNC ID: HGNC:8821