human LRRC8A Over-expression AAV

Cat. No: AAV-214592

Availability: 3-5 weeks

Name: AAV-h-LRRC8A

This is an AAV expressing Human LRRC8A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LRRC8A
Gene Name: leucine rich repeat containing 8 family member A
Gene ID: 56262
Gene Synonyms: AGM5; LRRC8; SWELL1
ORF Size: 2433 bp
RefSeq#: BC051322
Gene Description: LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
UniGene ID: Hs.643600
HGNC ID: HGNC:19027