Viral Details

Viral Backbone

Recombinant AAV

AAV-ITR

AAV2

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Gene Details

Species

Human

Gene Symbol

MBNL2

Gene Name

muscleblind like splicing regulator 2

Gene ID

10150

Gene Synonyms

MBLL; MBLL39; PRO2032

ORF Size

1122 bp

RefSeq#

BC104039

Gene Description

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. MBNL2 encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

UniGene ID

Hs.657347

HGNC ID

HGNC:16746