Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

DOCK3

Gene Name

dedicator of cytokinesis 3

Gene ID

1795

Gene Synonyms

MOCA; PBP

ORF Size

6090 bp

RefSeq#

BC156339

Gene Description

DOCK3 is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins (Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins) via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

UniGene ID

Hs.476284

HGNC ID

HGNC:2989