Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NR1H2

Gene Name

nuclear receptor subfamily 1 group H member 2

Gene ID

7376

Gene Synonyms

LXR-b; LXRB; NER; NER-I; RIP15; UNR

ORF Size

1386 bp

RefSeq#

BC007790

Gene Description

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 (PubMed 19436111)).(supplied by OMIM, Jan 2010)

UniGene ID

Hs.432976

HGNC ID

HGNC:7965