Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Tcf3

Gene Name

transcription factor 3

Gene ID

21423

Gene Synonyms

A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR

ORF Size

1959 bp

RefSeq#

BC018260

Gene Description

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

UniGene ID

Mm.3406