Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Crk

Gene Name

v-crk avian sarcoma virus CT10 oncogene homolog

Gene ID

12928

Gene Synonyms

c-Crk; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; p38

ORF Size

615 bp

RefSeq#

BC031149

Gene Description

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

UniGene ID

Mm.280125