Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CLCNKB

Gene Name

chloride voltage-gated channel Kb

Gene ID

1188

Gene Synonyms

ClC-K2; ClC-Kb; CLCKB

ORF Size

1389 bp

RefSeq#

BC020873

Gene Description

CLCNKB is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.352243

HGNC ID

HGNC:2027