AAV with GFAP(2.2) promoter driven ECFP

This AAV expresses ECFP driven by an astrocyte GFAP(2.2) promoter.

The GFAP(2.2) promoter is based on human glial fibrillary acidic protein gene (GFAP), which is the major intermediate filament protein in astrocytes. It has been shown that approximately 2 kb of 5'-flanking DNA of the human GFAP gene is sufficient to direct transgene expression to astrocytes and confer developmental/injury-induced regulation.

Enhanced Cyan fluorescence protein(ECFP) is a cyan variant from the Aequorea GFP, with a Excitation/Emission spectrum around 434nm/477nm. Other versions of fluorescent proteins with similar excitation and emission spectrums include mcerulean3, mTurquoise, and SCFP