AAV with SST promoter driven fLuc

This AAV expresses fLuc driven by an islet SST promoter.

The rat SST gene (also known as SS-14, SS-28, or Smst) is synthesized in the pancreatic islets, gastrointestinal tract, nervous system, and thyroid gland. The promoter (SSTp) is a 0.9Kb regulatory fragment from the rat SST gene.

Firefly luciferase (fLuc) is an oxidative enzyme used in bioluminescence and is distinct from a photoprotein. In the luciferase reaction, light is emitted when luciferase acts on the appropriate luciferin substrate. Photon emission can be detected by a light-sensitive apparatus such as a luminometer or modified optical microscope. Firefly luciferase is commonly used as a reporter to assess the transcriptional activity in cells.