Zinc regulates Nox1 expression through a NF-¿B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

Salazar G, etc
Free Radical Biology and Medicine, 2017

Increased Nox1 expression by zinc mediates senescence of VSMCs by telomere-dependent and -independent mechanisms.

  • Overexpression of ZnT3 or ZnT10 reduces Nox1 expression, while ZnT3 gene deficiency increases Nox1.

  • Zinc accumulates in mitochondria increasing mitochondrial ROS.

  • Zinc stimulates NF-¿B activation in VSMCs.

  • Inhibition of NF-¿B activation and reduction of mitochondrial ROS reduces Nox1 expression and prevents zinc-induced senescence.

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    • Journal
    Free Radical Biology and Medicine
    Year
    2017
    Page
    doi: 10.1016/j.freeradbiomed.2017.03.032
    Institute
    Florida State University

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